The LysR-type transcriptional regulator, CidR, regulates stationary phase cell death in Staphylococcus aureus.
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ABSTRACT:
SUBMITTER: Chaudhari SS
PROVIDER: S-EPMC5014633 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
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The LysR-type transcriptional regulator, CidR, regulates stationary phase cell death in Staphylococcus aureus.
Chaudhari Sujata S SS Thomas Vinai C VC Sadykov Marat R MR Bose Jeffrey L JL Ahn Daniel J DJ Zimmerman Matthew C MC Bayles Kenneth W KW
Molecular microbiology 20160704 6
The Staphylococcus aureus LysR-type transcriptional regulator, CidR, activates the expression of two operons including cidABC and alsSD that display pro- and anti-death functions, respectively. Although several investigations have focused on the functions of different genes associated with these operons, the collective role of the CidR regulon in staphylococcal physiology is not clearly understood. Here we reveal that the primary role of this regulon is to limit acetate-dependent potentiation of ...[more]
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