Ontology highlight
ABSTRACT:
SUBMITTER: Brackley AD
PROVIDER: S-EPMC5014669 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Brackley Allison Doyle AD Gomez Ruben R Akopian Armen N AN Henry Michael A MA Jeske Nathaniel A NA
Cell reports 20160825 10
Opioids remain the standard for analgesic care; however, adverse effects of systemic treatments contraindicate long-term administration. While most clinical opioids target mu opioid receptors (MOR), those that target the delta class (DOR) also demonstrate analgesic efficacy. Furthermore, peripherally restrictive opioids represent an attractive direction for analgesia. However, opioid receptors including DOR are analgesically incompetent in the absence of inflammation. Here, we report that G prot ...[more]