Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design.
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ABSTRACT:
SUBMITTER: Cui H
PROVIDER: S-EPMC5014673 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design.
Cui Haitao H Zhu Wei W Nowicki Margaret M Zhou Xuan X Khademhosseini Ali A Khademhosseini Ali A Zhang Lijie Grace LG
Advanced healthcare materials 20160707 17
A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional bone grafts with organized vascular networks. Biocompatible mussel-inspired chemistry and "thiol-ene" click reaction are used to regionally immobilize bioactive factors during construct fabrication for modulating or improving cellular events. ...[more]
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