Ontology highlight
ABSTRACT:
SUBMITTER: Yang HW
PROVIDER: S-EPMC5015690 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Yang Hee Won HW Collins Sean R SR Meyer Tobias T
Nature cell biology 20151221 2
Neutrophils and other amoeboid cells chemotax by steering their front ends towards chemoattractant. Although Ras, Rac, Cdc42 and RhoA small GTPases all regulate chemotaxis, it has been unclear how they spatiotemporally control polarization and steering. Using fluorescence biosensors in neutrophil-like PLB-985 cells and photorelease of chemoattractant, we show that local Cdc42 signals, but not those of Rac, RhoA or Ras, precede cell turning during chemotaxis. Furthermore, pre-existing local Cdc42 ...[more]