Compensation for Reflectance Variation in Vessel Density Quantification by Optical Coherence Tomography Angiography.

ABSTRACT:

Purpose

To compensate for reflectance variation when quantifying vessel density by optical coherence tomography angiography (OCTA).

Methods

Healthy participants received 6×6-mm macular and 4.5×4.5-mm optic nerve head (ONH) angiography scans on a 70-kHz spectral-domain optical coherence tomography system. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to compute the OCTA signal. Mean reflectance projection and maximum decorrelation projection were used to create en face OCT and OCTA images. Background OCTA noise in static tissue was evaluated in the foveal avascular zone (FAZ). Vessel density was calculated from en face retinal OCTA that was binarized according to a decorrelation threshold.

Results

The average retinal decorrelation no

SUBMITTER: Gao SS 

PROVIDER: S-EPMC5015963 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature