Ontology highlight
ABSTRACT:
SUBMITTER: Sheng R
PROVIDER: S-EPMC5016160 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Sheng Ren R Jung Da-Jung DJ Silkov Antonina A Kim Hyunjin H Singaram Indira I Wang Zhi-Gang ZG Xin Yao Y Kim Eui E Park Mi-Jeong MJ Thiagarajan-Rosenkranz Pallavi P Smrt Sean S Honig Barry B Baek Kwanghee K Ryu Sungho S Lorieau Justin J Kim You-Me YM Cho Wonhwa W
The Journal of biological chemistry 20160622 34
Lymphocyte-specific protein-tyrosine kinase (Lck) plays an essential role in T cell receptor (TCR) signaling and T cell development, but its activation mechanism is not fully understood. To explore the possibility that plasma membrane (PM) lipids control TCR signaling activities of Lck, we measured the membrane binding properties of its regulatory Src homology 2 (SH2) and Src homology 3 domains. The Lck SH2 domain binds anionic PM lipids with high affinity but with low specificity. Electrostatic ...[more]