Amphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry.
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ABSTRACT:
SUBMITTER: Xu F
PROVIDER: S-EPMC5016833 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Amphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry.
Xu Fengwen F Zhao Xiaoxiao X Hu Siqi S Li Jian J Yin Lijuan L Mei Shan S Liu Tingting T Wang Ying Y Ren Lili L Cen Shan S Zhao Zhendong Z Wang Jianwei J Jin Qi Q Liang Chen C Ai Bin B Guo Fei F
Scientific reports 20160909
Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease that leads to cardiopulmonary complications and death in young children. There is thus an urgent need to find new treatments to control EV71 infection. In this study, we report potent inhibition of EV71 by a polyene antibiotic Amphotericin B. Amphotericin B profoundly diminished the expression of EV71 RNA and viral proteins in the RD cells and the HEK293 cells. As a result, EV71 production was inhibited by Amphotericin B with an ...[more]
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