Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication.
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ABSTRACT:
SUBMITTER: Li ZH
PROVIDER: S-EPMC7109938 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication.
Li Zhao-Hong ZH Li Chien-Ming CM Ling Pin P Shen Fang-Hsiu FH Chen Shih-Heng SH Liu Ching-Chuan CC Yu Chun-Keung CK Chen Shun-Hua SH
The Journal of infectious diseases 20080301 6
Enterovirus 71 (EV71) causes fatal encephalitis in young children. However, there is no effective antiviral drug available for infected patients. Ribavirin is currently used for the treatment of several RNA virus infections clinically, so its anti-EV71 efficacy was evaluated. In vitro results showed that ribavirin effectively reduced the viral yields (with an IC50 of 65 microg/mL) and virus-induced cytopathic effect in human and mouse cell lines. In vivo results showed that ribavirin reduced the ...[more]
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