Ontology highlight
ABSTRACT:
SUBMITTER: Glas E
PROVIDER: S-EPMC5017209 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Glas Evi E Mückter Harald H Gudermann Thomas T Breit Andreas A
Scientific reports 20160909
Gs protein-coupled receptors regulate many vital body functions by activation of cAMP response elements (CRE) via cAMP-dependent kinase A (PKA)-mediated phosphorylation of the CRE binding protein (CREB). Melanocortin 4 receptors (MC4R) are prototypical Gs-coupled receptors that orchestrate the hypothalamic control of food-intake and metabolism. Remarkably, the significance of PKA for MC4R-induced CRE-dependent transcription in hypothalamic cells has not been rigorously interrogated yet. In two h ...[more]