Ontology highlight
ABSTRACT:
SUBMITTER: He X
PROVIDER: S-EPMC6918504 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
He Xi X Drelich Aleksandra A Yu Shangyi S Chang Qing Q Gong Dejun D Zhou Yixuan Y Qu Yue Y Yuan Yang Y Su Zhengchen Z Qiu Yuan Y Tang Shao-Jun SJ Gaitas Angelo A Ksiazek Thomas T Xu Zhiyun Z Zhou Jia J Feng Zongdi Z Wakamiya Maki M Lu Fanglin F Gong Bin B
Life sciences 20190207
Plasmin-mediated fibrinolysis at the surface of vascular endothelial cells (SVEC) plays a key role in maintaining vascular hemostasis, in which the cAMP pathway participates. After externalization to the SVEC, annexin A2 (ANXA2) serves as a platform for conversion of plasminogen to plasmin. Here we describe a regulatory role of the exchange protein directly activated by cAMP (EPAC) in ANXA2 externalization and vascular fibrinolysis. Knockout of EPAC1 in mice results in a decreased ANXA2 expressi ...[more]