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MicroRNA inhibition fine-tunes and provides robustness to the restriction point switch of the cell cycle.

ABSTRACT: The restriction point marks a switch in G1 from growth factor-dependent to growth factor-independent progression of the cell cycle. The proper regulation of this switch is important for normal cell processes; aberrations could result in a number of diseases such as cancer, neurodegenerative disorders, stroke and myocardial infarction. To further understand the regulation of the restriction point, we extended a mathematical model of the Rb-E2F pathway to include members of the microRNA cluster miR-17-92. Our mathematical analysis shows that microRNAs play an essential role in fine-tuning and providing robustness to the switch. We also demonstrate how microRNA regulation can steer cells in or out of cancer states.

SUBMITTER: Del Rosario RC

PROVIDER: S-EPMC5017317 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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MicroRNA inhibition fine-tunes and provides robustness to the restriction point switch of the cell cycle.

Del Rosario Ricardo C H RC Damasco Joseph Ray Clarence G JR Aguda Baltazar D BD

Scientific reports 20160909

The restriction point marks a switch in G1 from growth factor-dependent to growth factor-independent progression of the cell cycle. The proper regulation of this switch is important for normal cell processes; aberrations could result in a number of diseases such as cancer, neurodegenerative disorders, stroke and myocardial infarction. To further understand the regulation of the restriction point, we extended a mathematical model of the Rb-E2F pathway to include members of the microRNA cluster mi ...[more]

PMID: 27610602

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