Virtual Cortical Resection Reveals Push-Pull Network Control Preceding Seizure Evolution.

ABSTRACT: In ∼20 million people with drug-resistant epilepsy, focal seizures originating in dysfunctional brain networks will often evolve and spread to surrounding tissue, disrupting function in otherwise normal brain regions. To identify network control mechanisms that regulate seizure spread, we developed a novel tool for pinpointing brain regions that facilitate synchronization in the epileptic network. Our method measures the impact of virtually resecting putative control regions on synchronization in a validated model of the human epileptic network. By applying our technique to time-varying functional networks, we identified brain regions whose topological role is to synchronize or desynchronize the epileptic network. Our results suggest that greater antagonistic push-pull interaction between

SUBMITTER: Khambhati AN 

PROVIDER: S-EPMC5017915 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature