Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen TT
PROVIDER: S-EPMC5018766 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nguyen Trang Thi Thu TT Park Wei Sun WS Park Byung Ouk BO Kim Cha Yeon CY Oh Yohan Y Kim Jin Man JM Choi Hana H Kyung Taeyoon T Kim Cheol-Hee CH Lee Gabsang G Hahn Klaus M KM Meyer Tobias T Heo Won Do WD
Proceedings of the National Academy of Sciences of the United States of America 20160823 36
Cells migrate by directing Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division control protein 42 (Cdc42) activities and by polymerizing actin toward the leading edge of the cell. Previous studies have proposed that this polarization process requires a local positive feedback in the leading edge involving Rac small GTPase and actin polymerization with PI3K likely playing a coordinating role. Here, we show that the pleckstrin homology and RhoGEF domain containing G3 (PLEKHG3) is a ...[more]