Ontology highlight
ABSTRACT:
SUBMITTER: Cao J
PROVIDER: S-EPMC5738342 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Cao Jiahui J Ehling Manuel M März Sigrid S Seebach Jochen J Tarbashevich Katsiaryna K Sixta Tomas T Pitulescu Mara E ME Werner Ann-Cathrin AC Flach Boris B Montanez Eloi E Raz Erez E Adams Ralf H RH Schnittler Hans H
Nature communications 20171220 1
VEGFR-2/Notch signalling regulates angiogenesis in part by driving the remodelling of endothelial cell junctions and by inducing cell migration. Here, we show that VEGF-induced polarized cell elongation increases cell perimeter and decreases the relative VE-cadherin concentration at junctions, triggering polarized formation of actin-driven junction-associated intermittent lamellipodia (JAIL) under control of the WASP/WAVE/ARP2/3 complex. JAIL allow formation of new VE-cadherin adhesion sites tha ...[more]