Risk of Headache-Related Healthcare Visits in Patients With Celiac Disease: A Population-Based Observational Study.

ABSTRACT: BACKGROUND AND AIMS:Patients with celiac disease (CD) are reported to be at increased risk for headaches, though large studies are lacking. We aimed to examine the risk of headache-related healthcare encounters in patients with CD in a nationwide population-based setting. METHODS:In this population-based retrospective cohort study, we searched all (n?=?28) pathology departments in Sweden and identified patients with CD based on the presence of villous atrophy (VA). Each patient was matched to up to 5 controls, by age, gender, calendar period, and region. Using Cox proportional hazards, we tested for an association between CD and subsequent headache-related visit. We also tested this association for those with intestinal inflammation but normal villi, and subjects with positive CD serologies but normal histology. RESULTS:Among 28,638 patients with CD and 143,126 controls, headache-related visit occurred in 1,337 (4.7%) and 4,102 (2.9%), respectively. The incidence of headache-related visit was 423 per 100,000 person-years in CD patients and 254 per 100,000 person-years in controls (HR 1.66; 95% CI 1.56-1.77; P?

SUBMITTER: Lebwohl B 

PROVIDER: S-EPMC5018903 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature