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Optimized holographic femtosecond laser patterning method towards rapid integration of high-quality functional devices in microchannels.


ABSTRACT: Rapid integration of high-quality functional devices in microchannels is in highly demand for miniature lab-on-a-chip applications. This paper demonstrates the embellishment of existing microfluidic devices with integrated micropatterns via femtosecond laser MRAF-based holographic patterning (MHP) microfabrication, which proves two-photon polymerization (TPP) based on spatial light modulator (SLM) to be a rapid and powerful technology for chip functionalization. Optimized mixed region amplitude freedom (MRAF) algorithm has been used to generate high-quality shaped focus field. Base on the optimized parameters, a single-exposure approach is developed to fabricate 200 × 200 μm microstructure arrays in less than 240 ms. Moreover, microtraps, QR code and letters are integrated into a microdevice by the advanced method for particles capture and device identification. These results indicate that such a holographic laser embellishment of microfluidic devices is simple, flexible and easy to access, which has great potential in lab-on-a-chip applications of biological culture, chemical analyses and optofluidic devices.

SUBMITTER: Zhang C 

PROVIDER: S-EPMC5020409 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Optimized holographic femtosecond laser patterning method towards rapid integration of high-quality functional devices in microchannels.

Zhang Chenchu C   Hu Yanlei Y   Du Wenqiang W   Wu Peichao P   Rao Shenglong S   Cai Ze Z   Lao Zhaoxin Z   Xu Bing B   Ni Jincheng J   Li Jiawen J   Zhao Gang G   Wu Dong D   Chu Jiaru J   Sugioka Koji K  

Scientific reports 20160913


Rapid integration of high-quality functional devices in microchannels is in highly demand for miniature lab-on-a-chip applications. This paper demonstrates the embellishment of existing microfluidic devices with integrated micropatterns via femtosecond laser MRAF-based holographic patterning (MHP) microfabrication, which proves two-photon polymerization (TPP) based on spatial light modulator (SLM) to be a rapid and powerful technology for chip functionalization. Optimized mixed region amplitude  ...[more]

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