Lymphocyte-activation gene-3, an important immune checkpoint in cancer.
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ABSTRACT:
SUBMITTER: He Y
PROVIDER: S-EPMC5021038 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Lymphocyte-activation gene-3, an important immune checkpoint in cancer.
He Yayi Y Rivard Christopher J CJ Rozeboom Leslie L Yu Hui H Ellison Kim K Kowalewski Ashley A Zhou Caicun C Hirsch Fred R FR
Cancer science 20160825 9
Immunotherapy has recently become widely used in lung cancer. Many oncologists are focused on cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed cell death ligand-1 (PD-L1) and programmed cell death-1 (PD-1). Immunotherapy targeting the PD-1/PD-L1 checkpoints has shown promising efficacy in non-small cell lung cancer (NSCLC), but questions remain to be answered. Among them is whether the simultaneous inhibition of other checkpoints could improve outcomes. Lymphocyte-activation gene-3 (LAG-3) ...[more]
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