Injury, inflammation and the emergence of human-specific genes.
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ABSTRACT:
SUBMITTER: Baird A
PROVIDER: S-EPMC5021143 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Injury, inflammation and the emergence of human-specific genes.
Baird Andrew A Costantini Todd T Coimbra Raul R Eliceiri Brian P BP
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20160404 3
In light of the central role of inflammation in normal wound repair and regeneration, we hypothesize that the preponderance of human-specific genes expressed in human inflammatory cells is commensurate with the genetic versatility of inflammatory response and the emergence of injuries associated with uniquely hominid behaviors, like a bipedal posture and the use of tools, weapons and fire. The hypothesis underscores the need to study human-specific signaling pathways in experimental models of in ...[more]
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