Ontology highlight
ABSTRACT:
SUBMITTER: Pylypenko O
PROVIDER: S-EPMC5021521 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
eLife 20160913
There is growing evidence for a coupling of actin assembly and myosin motor activity in cells. However, mechanisms for recruitment of actin nucleators and motors on specific membrane compartments remain unclear. Here we report how Spir actin nucleators and myosin V motors coordinate their specific membrane recruitment. The myosin V globular tail domain (MyoV-GTD) interacts directly with an evolutionarily conserved Spir sequence motif. We determined crystal structures of MyoVa-GTD bound either to ...[more]