Design and engineering of artificial oxygen-activating metalloenzymes.
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ABSTRACT:
SUBMITTER: Nastri F
PROVIDER: S-EPMC5021598 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
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Design and engineering of artificial oxygen-activating metalloenzymes.
Nastri Flavia F Chino Marco M Maglio Ornella O Bhagi-Damodaran Ambika A Lu Yi Y Lombardi Angela A
Chemical Society reviews 20160624 18
Many efforts are being made in the design and engineering of metalloenzymes with catalytic properties fulfilling the needs of practical applications. Progress in this field has recently been accelerated by advances in computational, molecular and structural biology. This review article focuses on the recent examples of oxygen-activating metalloenzymes, developed through the strategies of de novo design, miniaturization processes and protein redesign. Considerable progress in these diverse design ...[more]
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