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Artificial Metalloenzymes: Challenges and Opportunities.

ABSTRACT: Artificial metalloenzymes (ArMs) result from the incorporation of an abiotic metal cofactor within a protein scaffold. From the earliest techniques of transition metals adsorbed on silk fibers, the field of ArMs has expanded dramatically over the past 60 years to encompass a range of reaction classes and inspired approaches: Assembly of the ArMs has taken multiple forms with both covalent and supramolecular anchoring strategies, while the scaffolds have been intuitively selected and evolved, repurposed, or designed in silico. Herein, we discuss some of the most prominent recent examples of ArMs to highlight the challenges and opportunities presented by the field.

SUBMITTER: Davis HJ

PROVIDER: S-EPMC6661864 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Artificial Metalloenzymes: Challenges and Opportunities.

Davis Holly J HJ Ward Thomas R TR

ACS central science 20190716 7

Artificial metalloenzymes (ArMs) result from the incorporation of an abiotic metal cofactor within a protein scaffold. From the earliest techniques of transition metals adsorbed on silk fibers, the field of ArMs has expanded dramatically over the past 60 years to encompass a range of reaction classes and inspired approaches: Assembly of the ArMs has taken multiple forms with both covalent and supramolecular anchoring strategies, while the scaffolds have been intuitively selected and evolved, rep ...[more]

PMID: 31404244

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Artificial Metalloenzymes: Challenges and Opportunities.

Publications

Artificial Metalloenzymes: Challenges and Opportunities.

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