Ontology highlight
ABSTRACT:
SUBMITTER: TeSlaa T
PROVIDER: S-EPMC5023506 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
TeSlaa Tara T Chaikovsky Andrea C AC Lipchina Inna I Escobar Sandra L SL Hochedlinger Konrad K Huang Jing J Graeber Thomas G TG Braas Daniel D Teitell Michael A MA
Cell metabolism 20160728 3
Pluripotent stem cells (PSCs) can self-renew or differentiate from naive or more differentiated, primed, pluripotent states established by specific culture conditions. Increased intracellular α-ketoglutarate (αKG) was shown to favor self-renewal in naive mouse embryonic stem cells (mESCs). The effect of αKG or αKG/succinate levels on differentiation from primed human PSCs (hPSCs) or mouse epiblast stem cells (EpiSCs) remains unknown. We examined primed hPSCs and EpiSCs and show that increased αK ...[more]