Ontology highlight
ABSTRACT:
SUBMITTER: Akiyama T
PROVIDER: S-EPMC5087640 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Akiyama Tomohiko T Wakabayashi Shunichi S Soma Atsumi A Sato Saeko S Nakatake Yuhki Y Oda Mayumi M Murakami Miyako M Sakota Miki M Chikazawa-Nohtomi Nana N Ko Shigeru B H SB Ko Minoru S H MS
Development (Cambridge, England) 20161001 20
Harnessing epigenetic regulation is crucial for the efficient and proper differentiation of pluripotent stem cells (PSCs) into desired cell types. Histone H3 lysine 27 trimethylation (H3K27me3) functions as a barrier against cell differentiation through the suppression of developmental gene expression in PSCs. Here, we have generated human PSC (hPSC) lines in which genome-wide reduction of H3K27me3 can be induced by ectopic expression of the catalytic domain of the histone demethylase JMJD3 (cal ...[more]