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Wnt/?-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration.

ABSTRACT: The Wnt/?-catenin pathway is an evolutionarily conserved set of signals with critical roles in embryonic and neonatal development across species. In mammals the pathway is quiescent in many organs. It is reactivated in response to injury and is reported to play complex and contrasting roles in promoting regeneration and fibrosis. We review the current understanding of the role of the Wnt/?-catenin pathway in injury of various mammalian organs and discuss the current advances and potential of Wnt inhibitory therapeutics toward promoting tissue regeneration and reducing fibrosis.-Bastakoty, D., Young, P. P. Wnt/?-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration.

SUBMITTER: Bastakoty D

PROVIDER: S-EPMC5024694 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration.

Bastakoty Dikshya D Young Pampee P PP

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20160622 10

The Wnt/β-catenin pathway is an evolutionarily conserved set of signals with critical roles in embryonic and neonatal development across species. In mammals the pathway is quiescent in many organs. It is reactivated in response to injury and is reported to play complex and contrasting roles in promoting regeneration and fibrosis. We review the current understanding of the role of the Wnt/β-catenin pathway in injury of various mammalian organs and discuss the current advances and potential of Wnt ...[more]

PMID: 27335371

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