Ontology highlight
ABSTRACT:
SUBMITTER: Villareal VA
PROVIDER: S-EPMC5025300 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Villareal Valerie A VA Fu Dan D Costello Deirdre A DA Xie Xiaoliang Sunney XS Yang Priscilla L PL
ACS chemical biology 20160506 7
Hepatitis C virus (HCV) increases intracellular desmosterol without affecting the steady-state abundance of other sterols, and the antiviral activity of inhibitors of desmosterol synthesis is suppressed by the addition of exogenous desmosterol. These observations suggest a model in which desmosterol has a specific function, direct or indirect, in HCV replication and that HCV alters desmosterol homeostasis to promote viral replication. Here, we use stimulated Raman scattering (SRS) microscopy in ...[more]