Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5025750 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Wang Yang Y Zhang Yi Y Chen Lianwan L Liang Qian Q Yin Xiao-Ming XM Miao Long L Kang Byung-Ho BH Xue Ding D
Nature communications 20160901
In most eukaryotes, mitochondria are inherited maternally. The autophagy process is critical for paternal mitochondrial elimination (PME) in Caenorhabditis elegans, but how paternal mitochondria, but not maternal mitochondria, are selectively targeted for degradation is poorly understood. Here we report that mitochondrial dynamics have a profound effect on PME. A defect in fission of paternal mitochondria delays PME, whereas a defect in fusion of paternal mitochondria accelerates PME. Surprising ...[more]