Ontology highlight
ABSTRACT:
SUBMITTER: Lim Y
PROVIDER: S-EPMC6717525 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Lim Yunki Y Rubio-Peña Karinna K Sobraske Peter J PJ Molina Paola A PA Brookes Paul S PS Galy Vincent V Nehrke Keith K
Developmental biology 20190621 1
Paternal mitochondria are eliminated following fertilization by selective autophagy, but the mechanisms that restrict this process to sperm-derived organelles are not well understood. FUNDC1 (FUN14 domain containing 1) is a mammalian mitophagy receptor expressed on the mitochondrial outer membrane that contributes to mitochondrial quality control following hypoxic stress. Like FUNDC1, the C. elegans ortholog FNDC-1 is widely expressed in somatic tissues and mediates hypoxic mitophagy. Here, we r ...[more]