Ontology highlight
ABSTRACT:
SUBMITTER: Vikram A
PROVIDER: S-EPMC5025761 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Vikram Ajit A Kim Young-Rae YR Kumar Santosh S Li Qiuxia Q Kassan Modar M Jacobs Julia S JS Irani Kaikobad K
Nature communications 20160902
Gut microbiota promotes atherosclerosis, and vascular endothelial dysfunction, signalled by impaired endothelium-dependent vasorelaxation, is an early marker of atherosclerosis. Here we show that vascular microRNA-204 (miR-204) expression is remotely regulated by the microbiome, and impairs endothelial function by targeting the Sirtuin1 lysine deacetylase (Sirt1). MiR-204 is downregulated, while Sirt1 is upregulated, in aortas of germ-free mice. Suppression of gut microbiome with broad-spectrum ...[more]