Ontology highlight
ABSTRACT:
SUBMITTER: Jackson-Jones LH
PROVIDER: S-EPMC5025788 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Jackson-Jones Lucy H LH Duncan Sheelagh M SM Magalhaes Marlène S MS Campbell Sharon M SM Maizels Rick M RM McSorley Henry J HJ Allen Judith E JE Bénézech Cécile C
Nature communications 20160901
Fat-associated lymphoid clusters (FALC) are inducible structures that support rapid innate-like B-cell immune responses in the serous cavities. Little is known about the physiological cues that activate FALCs in the pleural cavity and more generally the mechanisms controlling B-cell activation in FALCs. Here we show, using separate models of pleural nematode infection with Litomosoides sigmodontis and Altenaria alternata induced acute lung inflammation, that inflammation of the pleural cavity ra ...[more]