Ontology highlight
ABSTRACT:
SUBMITTER: Gordon SN
PROVIDER: S-EPMC5026031 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Gordon Shari N SN Liyanage Namal P M NP Doster Melvin N MN Vaccari Monica M Vargas-Inchaustegui Diego A DA Pegu Poonam P Schifanella Luca L Shen Xiaoying X Tomaras Georgia D GD Rao Mangala M Billings Erik A EA Schwartz Jennifer J Prado Ilia I Bobb Kathryn K Zhang Wenlei W Montefiori David C DC Foulds Kathryn E KE Ferrari Guido G Robert-Guroff Marjorie M Roederer Mario M Phan Tran B TB Forthal Donald N DN Stablein Donald M DM Phogat Sanjay S Venzon David J DJ Fouts Timothy T Franchini Genoveffa G
Journal of immunology (Baltimore, Md. : 1950) 20160902 7
The recombinant ALVAC vaccine coupled with the monomeric gp120/alum protein have decreased the risk of HIV and SIV acquisition. Ab responses to the V1/V2 regions have correlated with a decreased risk of virus acquisition in both humans and macaques. We hypothesized that the breadth and functional profile of Abs induced by an ALVAC/envelope protein regimen could be improved by substituting the monomeric gp120 boost, with the full-length single-chain (FLSC) protein. FLSC is a CD4-gp120 fusion immu ...[more]