Ontology highlight
ABSTRACT:
SUBMITTER: Gorini G
PROVIDER: S-EPMC7093029 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Gorini Giacomo G Fourati Slim S Vaccari Monica M Rahman Mohammad Arif MA Gordon Shari N SN Brown Dallas R DR Law Lynn L Chang Jean J Green Richard R Barrenäs Fredrik F Liyanage Namal P M NPM Doster Melvin N MN Schifanella Luca L Bissa Massimiliano M Silva de Castro Isabela I Washington-Parks Robyn R Galli Veronica V Fuller Deborah H DH Santra Sampa S Agy Michael M Pal Ranajit R Palermo Robert E RE Tomaras Georgia D GD Shen Xiaoying X LaBranche Celia C CC Montefiori David C DC Venzon David J DJ Trinh Hung V HV Rao Mangala M Gale Michael M Sekaly Rafick P RP Franchini Genoveffa G
PLoS pathogens 20200312 3
The recombinant Canarypox ALVAC-HIV/gp120/alum vaccine regimen was the first to significantly decrease the risk of HIV acquisition in humans, with equal effectiveness in both males and females. Similarly, an equivalent SIV-based ALVAC vaccine regimen decreased the risk of virus acquisition in Indian rhesus macaques of both sexes following intrarectal exposure to low doses of SIVmac251. Here, we demonstrate that the ALVAC-SIV/gp120/alum vaccine is also efficacious in female Chinese rhesus macaque ...[more]