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Comment on "Multiple repressive mechanisms in the hippocampus during memory formation".

ABSTRACT: Cho et al. (Reports, 2 October 2015, p. 82) report that gene repression after contextual fear conditioning regulates hippocampal memory formation. We observe low levels of expression for many of the top candidate genes in the hippocampus and robust expression in the choroid plexus, as well as repression at 4 hours after contextual fear conditioning, suggesting the inclusion of choroid plexus messenger RNAs in Cho et al. hippocampal samples.

SUBMITTER: Mathew RS

PROVIDER: S-EPMC5026305 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Comment on "Multiple repressive mechanisms in the hippocampus during memory formation".

Mathew Rebecca S RS Mullan Hillary H Blusztajn Jan Krzysztof JK Lehtinen Maria K MK

Science (New York, N.Y.) 20160701 6298

Cho et al. (Reports, 2 October 2015, p. 82) report that gene repression after contextual fear conditioning regulates hippocampal memory formation. We observe low levels of expression for many of the top candidate genes in the hippocampus and robust expression in the choroid plexus, as well as repression at 4 hours after contextual fear conditioning, suggesting the inclusion of choroid plexus messenger RNAs in Cho et al. hippocampal samples. ...[more]

PMID: 27482552

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