Ontology highlight
ABSTRACT:
SUBMITTER: Lichtenstein BR
PROVIDER: S-EPMC5026455 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20150914 46
The first principles design of manmade redox-protein maquettes is used to clarify the physical/chemical engineering supporting the mechanisms of natural enzymes with a view to recapitulate and surpass natural performance. Herein, we use intein-based protein semisynthesis to pair a synthetic naphthoquinone amino acid (Naq) with histidine-ligated photoactive metal-tetrapyrrole cofactors, creating a 100 μs photochemical charge separation unit akin to photosynthetic reaction centers. By using propar ...[more]