Unknown

Dataset Information

0

Entrapment neuropathies in diabetes mellitus.


ABSTRACT: Neuropathy is a common complication of diabetes mellitus (DM) with a wide clinical spectrum that encompasses generalized to focal and multifocal forms. Entrapment neuropathies (EN), which are focal forms, are so frequent at any stage of the diabetic disease, that they may be considered a neurophysiological hallmark of peripheral nerve involvement in DM. Indeed, EN may be the earliest neurophysiological abnormalities in DM, particularly in the upper limbs, even in the absence of a generalized polyneuropathy, or it may be superimposed on a generalized diabetic neuropathy. This remarkable frequency of EN in diabetes is underlain by a peculiar pathophysiological background. Due to the metabolic alterations consequent to abnormal glucose metabolism, the peripheral nerves show both functional impairment and structural changes, even in the preclinical stage, making them more prone to entrapment in anatomically constrained channels. This review discusses the most common and relevant EN encountered in diabetic patient in their epidemiological, pathophysiological and diagnostic features.

SUBMITTER: Rota E 

PROVIDER: S-EPMC5027001 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Entrapment neuropathies in diabetes mellitus.

Rota Eugenia E   Morelli Nicola N  

World journal of diabetes 20160901 17


Neuropathy is a common complication of diabetes mellitus (DM) with a wide clinical spectrum that encompasses generalized to focal and multifocal forms. Entrapment neuropathies (EN), which are focal forms, are so frequent at any stage of the diabetic disease, that they may be considered a neurophysiological hallmark of peripheral nerve involvement in DM. Indeed, EN may be the earliest neurophysiological abnormalities in DM, particularly in the upper limbs, even in the absence of a generalized pol  ...[more]

Similar Datasets

| S-EPMC8914073 | biostudies-literature
2017-04-22 | GSE98043 | GEO
| PRJEB51173 | ENA
2023-10-24 | PXD042188 | Pride
2010-12-18 | GSE26168 | GEO
2010-12-18 | E-GEOD-26168 | biostudies-arrayexpress
2021-07-17 | E-MTAB-9255 | biostudies-arrayexpress
2020-05-26 | PXD012667 | Pride
2020-07-07 | GSE144276 | GEO
2017-02-09 | GSE94649 | GEO