Ontology highlight
ABSTRACT:
SUBMITTER: Vakulskas CA
PROVIDER: S-EPMC5027483 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Vakulskas Christopher A CA Leng Yuanyuan Y Abe Hazuki H Amaki Takumi T Okayama Akihiro A Babitzke Paul P Suzuki Kazushi K Romeo Tony T
Nucleic acids research 20160527 16
The widely conserved protein CsrA (carbon storage regulator A) globally regulates bacterial gene expression at the post-transcriptional level. In many species, CsrA activity is governed by untranslated sRNAs, CsrB and CsrC in Escherichia coli, which bind to multiple CsrA dimers, sequestering them from lower affinity mRNA targets. Both the synthesis and turnover of CsrB/C are regulated. Their turnover requires the housekeeping endonuclease RNase E and is activated by the presence of a preferred c ...[more]