Ontology highlight
ABSTRACT:
SUBMITTER: Nishioka H
PROVIDER: S-EPMC5027582 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nishioka Hisae H Tooi Norie N Isobe Takehisa T Nakatsuji Norio N Aiba Kazuhiro K
Scientific reports 20160919
Alzheimer's disease (AD) is the most common form of dementia. Cellular AD models derived from human pluripotent stem cells are promising tools in AD research. We recently developed human embryonic stem cell-derived AD models which overexpress mutant Presenilin1 genes, and which exhibit AD phenotypes, including synaptic dysfunction. In this study, we found that our AD models showed reduced levels of RAB3A and SV2B proteins in the pre-synapses, which is a possible cause of electrophysiological abn ...[more]