Ontology highlight
ABSTRACT:
SUBMITTER: Liu YW
PROVIDER: S-EPMC6329375 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Liu Yen-Wen YW Chen Billy B Yang Xiulan X Fugate James A JA Kalucki Faith A FA Futakuchi-Tsuchida Akiko A Couture Larry L Vogel Keith W KW Astley Clifford A CA Baldessari Audrey A Ogle Jason J Don Creighton W CW Steinberg Zachary L ZL Seslar Stephen P SP Tuck Stephanie A SA Tsuchida Hiroshi H Naumova Anna V AV Dupras Sarah K SK Lyu Milly S MS Lee James J Hailey Dale W DW Reinecke Hans H Pabon Lil L Fryer Benjamin H BH MacLellan W Robb WR Thies R Scott RS Murry Charles E CE
Nature biotechnology 20180702 7
Pluripotent stem cell-derived cardiomyocyte grafts can remuscularize substantial amounts of infarcted myocardium and beat in synchrony with the heart, but in some settings cause ventricular arrhythmias. It is unknown whether human cardiomyocytes can restore cardiac function in a physiologically relevant large animal model. Here we show that transplantation of ∼750 million cryopreserved human embryonic stem cell-derived cardiomyocytes (hESC-CMs) enhances cardiac function in macaque monkeys with l ...[more]