Ontology highlight
ABSTRACT:
SUBMITTER: King KC
PROVIDER: S-EPMC5029159 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
King Kayla C KC Brockhurst Michael A MA Vasieva Olga O Paterson Steve S Betts Alex A Ford Suzanne A SA Frost Crystal L CL Horsburgh Malcolm J MJ Haldenby Sam S Hurst Gregory Dd GD
The ISME journal 20160315 8
Microbes can defend their host against virulent infections, but direct evidence for the adaptive origin of microbe-mediated protection is lacking. Using experimental evolution of a novel, tripartite interaction, we demonstrate that mildly pathogenic bacteria (Enterococcus faecalis) living in worms (Caenorhabditis elegans) rapidly evolved to defend their animal hosts against infection by a more virulent pathogen (Staphylococcus aureus), crossing the parasitism-mutualism continuum. Host protection ...[more]