Ontology highlight
ABSTRACT:
SUBMITTER: Ramos-Espiritu L
PROVIDER: S-EPMC5030147 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Ramos-Espiritu Lavoisier L Kleinboelting Silke S Navarrete Felipe A FA Alvau Antonio A Visconti Pablo E PE Valsecchi Federica F Starkov Anatoly A Manfredi Giovanni G Buck Hannes H Adura Carolina C Zippin Jonathan H JH van den Heuvel Joop J Glickman J Fraser JF Steegborn Clemens C Levin Lonny R LR Buck Jochen J
Nature chemical biology 20160822 10
The prototypical second messenger cAMP regulates a wide variety of physiological processes. It can simultaneously mediate diverse functions by acting locally in independently regulated microdomains. In mammalian cells, two types of adenylyl cyclase generate cAMP: G-protein-regulated transmembrane adenylyl cyclases and bicarbonate-, calcium- and ATP-regulated soluble adenylyl cyclase (sAC). Because each type of cyclase regulates distinct microdomains, methods to distinguish between them are neede ...[more]