Circulating Fibroblast Growth Factor 21 is Associated with Diastolic Dysfunction in Heart Failure Patients with Preserved Ejection Fraction.
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ABSTRACT:
SUBMITTER: Chou RH
PROVIDER: S-EPMC5030655 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
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Circulating Fibroblast Growth Factor 21 is Associated with Diastolic Dysfunction in Heart Failure Patients with Preserved Ejection Fraction.
Chou Ruey-Hsing RH Huang Po-Hsun PH Hsu Chien-Yi CY Chang Chun-Chin CC Leu Hsin-Bang HB Huang Chin-Chou CC Chen Jaw-Wen JW Lin Shing-Jong SJ
Scientific reports 20160921
Fibroblast growth factor 21 (FGF21), a polypeptide ligand promoted glucose homeostasis and lipids metabolism, was recently reported to attenuate cardiac hypertrophy. The aim of this study was to investigate the impact of FGF21 in diastolic heart failure. Subjects admitted for coronary angiogram were screened for heart failure, and those with left ventricular (LV) ejection fraction < 45% were excluded. Diastolic dysfunction was defined as functional abnormalities that exist during LV relaxation a ...[more]
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