Stochastic Kinetics of Nascent RNA.
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ABSTRACT:
SUBMITTER: Xu H
PROVIDER: S-EPMC5033037 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Stochastic Kinetics of Nascent RNA.
Xu Heng H Skinner Samuel O SO Sokac Anna Marie AM Golding Ido I
Physical review letters 20160913 12
The stochastic kinetics of transcription is typically inferred from the distribution of RNA numbers in individual cells. However, cellular RNA reflects additional processes downstream of transcription, hampering this analysis. In contrast, nascent (actively transcribed) RNA closely reflects the kinetics of transcription. We present a theoretical model for the stochastic kinetics of nascent RNA, which we solve to obtain the probability distribution of nascent RNA per gene. The model allows us to ...[more]
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