Ontology highlight
ABSTRACT:
SUBMITTER: Kotoku T
PROVIDER: S-EPMC5034229 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kotoku Tomomi T Kosaka Koji K Nishio Miki M Ishida Yasumasa Y Kawaichi Masashi M Matsuda Eishou E
Scientific reports 20160923
The molecular mechanisms underlying mesodermal and cardiac specification from embryonic stem cells (ESCs) are not fully understood. Here, we showed that the BTB domain-containing zinc finger protein CIBZ is expressed in mouse ESCs but is dramatically downregulated during ESC differentiation. CIBZ deletion in ESCs induced specification toward mesoderm phenotypes and their differentiation into cardiomyocytes, whereas overexpression of CIBZ delayed these processes. During ESC differentiation, CIBZ ...[more]