Ontology highlight
ABSTRACT:
SUBMITTER: Wells MA
PROVIDER: S-EPMC5035202 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Wells Michael A MA Vendrov Kimberly C KC Edin Matthew L ML Ferslew Brian C BC Zha Weibin W Nguyen Bobbie K H BK Church Rachel J RJ Lih Fred B FB DeGraff Laura M LM Brouwer Kim L R KL Barritt A Sidney AS Zeldin Darryl C DC Lee Craig R CR
Prostaglandins & other lipid mediators 20160709
Non-alcoholic steatohepatitis (NASH) is an emerging public health problem without effective therapies. Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into bioactive epoxyeicosatrienoic acids (EETs), which have potent anti-inflammatory and protective effects. However, the functional relevance of the CYP epoxyeicosanoid metabolism pathway in the pathogenesis of NASH remains poorly understood. Our studies demonstrate that both mice with methionine-choline deficient (MCD) diet-induce ...[more]