Genetics of alcoholic liver disease and non-alcoholic steatohepatitis.
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SUBMITTER: Scott E
PROVIDER: S-EPMC6334028 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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Genetics of alcoholic liver disease and non-alcoholic steatohepatitis.
Scott Emma E Anstee Quentin M QM
Clinical medicine (London, England) 20180401 Suppl 2
Alcohol-related liver disease (ARLD) and non-alcoholic fatty liver disease (NAFLD) are leading causes of chronic liver disease globally. Both ARLD and NAFLD are multifactorial and refer to a spectrum of disease severity, ranging from steatosis through steatohepatitis to fibrosis and cirrhosis. Both diseases exhibit substantial inter-patient variation in long-term outcomes and are best considered complex disease traits where genetic and environmental factors interact to mediate disease severity a ...[more]
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