Ontology highlight
ABSTRACT:
SUBMITTER: Starrett GJ
PROVIDER: S-EPMC5036005 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Starrett Gabriel J GJ Luengas Elizabeth M EM McCann Jennifer L JL Ebrahimi Diako D Temiz Nuri A NA Love Robin P RP Feng Yuqing Y Adolph Madison B MB Chelico Linda L Law Emily K EK Carpenter Michael A MA Harris Reuben S RS
Nature communications 20160921
Cytosine mutations within TCA/T motifs are common in cancer. A likely cause is the DNA cytosine deaminase APOBEC3B (A3B). However, A3B-null breast tumours still have this mutational bias. Here we show that APOBEC3H haplotype I (A3H-I) provides a likely solution to this paradox. A3B-null tumours with this mutational bias have at least one copy of A3H-I despite little genetic linkage between these genes. Although deemed inactive previously, A3H-I has robust activity in biochemical and cellular ass ...[more]