Ontology highlight
ABSTRACT:
SUBMITTER: Zhou S
PROVIDER: S-EPMC5037396 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Zhou Saijun S Chen Gang G Qi Miao M El-Assaad Fatima F Wang Ying Y Dong Shangwen S Chen Liming L Yu Demin D Weaver James C JC Beretov Julia J Krilis Steven A SA Giannakopoulos Bill B
Scientific reports 20160927
Lipopolysaccharide (LPS) is a major component of the outer wall of gram negative bacteria. In high doses LPS contributes to the inflammation in gram negative sepsis, and in low doses contributes to the low grade inflammation characteristic of the metabolic syndrome. We wanted to assess the role of beta2-glycoprotein I (β2GPI) a highly conserved plasma protein and its different biochemical forms in a mouse model of LPS systemic inflammation. Normal and β2GPI deficient mice were administered LPS t ...[more]