Ontology highlight
ABSTRACT:
SUBMITTER: Bazou D
PROVIDER: S-EPMC5037418 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Bazou Despina D Ng Mei Rosa MR Song Jonathan W JW Chin Shan Min SM Maimon Nir N Munn Lance L LL
Scientific reports 20160927
Angiogenesis requires the coordinated growth and migration of endothelial cells (ECs), with each EC residing in the vessel wall integrating local signals to determine whether to remain quiescent or undergo morphogenesis. These signals include vascular endothelial growth factor (VEGF) and flow-induced mechanical stimuli such as interstitial flow, which are both elevated in the tumor microenvironment. However, it is not clear how VEGF signaling and mechanobiological activation due to interstitial ...[more]