Dataset Information

Associations between Dietary Patterns, ADR?2 Gln27Glu and ADR?3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study.

ABSTRACT: Interactions between dietary patterns and 2 ?-adrenergic receptor (ADR?) gene polymorphisms (ADR?2 Gln27Glu and ADR?3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35-69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 items from a validated short food frequency questionnaire and examined major dietary patterns by factor analysis. We identified four dietary patterns: healthy, Western, seafood and bread patterns. There was no significant association between any dietary pattern and serum triglyceride levels. After a separate genotype-based analysis, significant interactions between ADR?3 Trp64Arg genotype and the bread pattern (p for interaction = 0.01) were associated with serum triglyceride levels; specifically, after adjusting for confounding factors, Arg allele carriers with the bread pattern had lower serum triglycerides (p for trend = 0.01). However, the Trp/Trp homozygous subjects with the bread pattern showed no association with serum triglycerides (p for trend = 0.55). Interactions between other dietary patterns and ADR? polymorphisms were not significant for serum triglyceride levels. Our findings suggest that ADR?3 polymorphism modifies the effects of the bread pattern on triglyceride levels.

SUBMITTER: Nanri H

PROVIDER: S-EPMC5037531 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Associations between Dietary Patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study.

Nanri Hinako H Nishida Yuichiro Y Nakamura Kazuyo K Tanaka Keitaro K Naito Mariko M Yin Guang G Hamajima Nobuyuki N Takashima Naoyuki N Suzuki Sadao S Nindita Yora Y Kohno Michiko M Uemura Hirokazu H Koyama Teruhide T Hosono Satoyo S Mikami Haruo H Kubo Michiaki M Tanaka Hideo H

Nutrients 20160906 9

Interactions between dietary patterns and 2 β-adrenergic receptor (ADRβ) gene polymorphisms (ADRβ2 Gln27Glu and ADRβ3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35-69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 items from a validated short food frequency que ...[more]

PMID: 27608039

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Project description:Breast cancer is the most prevalent cancer in females worldwide. Studies evaluating the blood vitamins and minerals status in the breast cancer etiology are limited, and the results are inconclusive. This study analyzed the association between serum vitamin-mineral profiles (V-MPs) and breast cancer (BC) risk with including dietary patterns (DPs) and the use of supplements. This case-control study involved 420 women aged 40-79 years from north-eastern Poland, including 190 newly diagnosed breast cancer cases. The fasting serum concentrations of vitamins (folate, cobalamin, 25(OH) vitamin D) and minerals (iron, calcium, magnesium) were measured in 129 post-menopausal women, including 82 controls and 47 cases. Three V-MPs were derived with a Principal Component Analysis (PCA). A logistic regression analysis was performed to estimate the odds ratio (OR) and 95% confidence interval (95% CI) of the breast cancer risk associated with serum V-MPs and serum levels of single biomarkers. The risk of BC was lower by 88% (OR: 0.12; 95% Cl: 0.02-0.88; p < 0.05) in the upper tertile of the serum 'Iron-Calcium' profile compared to the bottom tertile, lower by 67% (OR: 0.33; 95% Cl: 0.11-0.97; p < 0.05) at the level of serum 25(OH) vitamin D ?24.6 ng/mL and lower by 68% (OR: 0.32; 95% Cl: 0.11-0.91; p < 0.05) at the level of serum calcium ?9.6 mg/dL. There was an inverse association of the serum 'Magnesium' profile or serum level of iron with the risk of BC, which disappeared after adjustment for the set of confounders accounted for: age, body mass index (BMI), socioeconomic status, overall physical activity, smoking status, age at menarche, number of full-term pregnancies, oral contraceptive use, hormone-replacement therapy use, family history of breast cancer, vitamin/mineral supplement use, the molecular subtype of breast cancer, and dietary patterns. No significant association was found between BC risk and the serum 'Folate-Cobalamin-Vitamin D' profile or serum folate, cobalamin or magnesium considered separately. These findings highlight that a higher-normal serum level of both iron and calcium, considered together as the serum profile, as well as a higher-normal serum level of calcium, considered separately, and a slightly below the normal range of serum vitamin D level may protect against breast cancer among postmenopausal women, independent of dietary patterns or the use of vitamin/mineral supplements. Therefore, the maintenance of the adequate status of vitamins and minerals and the regular monitoring of their blood markers should be included in breast cancer prevention.

Dataset Information

Associations between Dietary Patterns, ADR?2 Gln27Glu and ADR?3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study.

Publications

Associations between Dietary Patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study.

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