Ontology highlight
ABSTRACT:
SUBMITTER: Chou C
PROVIDER: S-EPMC5037962 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Chou Chun C Verbaro Daniel J DJ Tonc Elena E Holmgren Melanie M Cella Marina M Colonna Marco M Bhattacharya Deepta D Egawa Takeshi T
Immunity 20160823 3
B cells diversify and affinity mature their antigen receptor repertoire in germinal centers (GCs). GC B cells receive help signals during transient interaction with T cells, yet it remains unknown how these transient T-B interactions in the light zone sustain the subsequent proliferative program of selected B cells that occurs in the anatomically distant dark zone. Here, we show that the transcription factor AP4 was required for sustained GC B cell proliferation and subsequent establishment of a ...[more]