Ontology highlight
ABSTRACT:
SUBMITTER: Fallet B
PROVIDER: S-EPMC6996002 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Fallet Bénédict B Hao Yi Y Florova Marianna M Cornille Karen K de Los Aires Alba Verge AV Girelli Zubani Giulia G Ertuna Yusuf I YI Greiff Victor V Menzel Ulrike U Hammad Karim K Merkler Doron D Reddy Sai T ST Weill Jean-Claude JC Reynaud Claude-Agnès CA Pinschewer Daniel D DD
Cell reports 20200101 4
Persistent viral infections subvert key elements of adaptive immunity. To compare germinal center (GC) B cell responses in chronic and acute lymphocytic choriomeningitis virus infection, we exploit activation-induced deaminase (AID) fate-reporter mice and perform adoptive B cell transfer experiments. Chronic infection yields GC B cell responses of higher cellularity than acute infections do, higher memory B cell and antibody secreting cell output for longer periods of time, a better representati ...[more]